Organoid-on-a-Chip

Organoid chips

Organoid-on-a-Chip

We are a one-stop CDMO for organoid-on-a-chip and organ-on-a-chip programs: chip design and engineering, PDMS rapid prototyping, thermoplastic injection molding for scale-up, glass and silicon MEMS processing, surface functionalization, bonding, assembly and QC — all delivered inside an ISO 13485 quality system.

Product Advantages

ISO 13485 certifiedMedical-device QMS
FDA registeredEstablishment registration
ISO 7 cleanroomControlled molding & assembly
PDMS → COC/COPPrototype-to-production path

01

CDMO services

Six capability blocks covering the full chip lifecycle

Chip design & engineering

Design-for-manufacturing review of your architecture: channel geometry vs. shear budget, membrane pore selection, dead-volume optimization, and material selection (PDMS, COC/COP, PMMA, glass, silicon) matched to your assay chemistry.

  • DFM review
  • Shear & diffusion modeling
  • AutoCAD / GDS handoff
  • Design verification builds

PDMS rapid prototyping

Fast iteration on soft lithography: master fabrication, PDMS replica molding, plasma bonding, and interchangeable layer stacks. The fastest route from a literature design to a working device in your lab.

  • Soft lithography
  • Multilayer alignment
  • Plasma bonding >60 psi
  • Slide / well-plate formats

Injection molding & scale-up

Transfer your prototype into a thermoplastic cartridge: tool design, ISO 7 cleanroom injection molding of COC/COP/PMMA/PS, thermal and solvent bonding, and validated process windows for volume production.

  • Tooling & mold flow
  • COC / COP / PMMA / PS
  • Cleanroom molding
  • Volume: pilot → millions/yr

Glass & silicon (MEMS)

High-rigidity, optically superior substrates for advanced assays: etched silicon and glass microstructures, anodic bonding, and hybrid glass-plastic assemblies with sub-micron feature fidelity.

  • DRIE / wet etch
  • Anodic bonding
  • Glass thru-holes
  • Hybrid assemblies

Surface functionalization

Assay-critical surface chemistry: ECM coatings (Matrigel, collagen I/IV, fibronectin, laminin), plasma and chemical grafting for wettability control, bubble-free priming treatments, and drug-adsorption mitigation strategies.

  • ECM coating
  • Plasma / grafting
  • Hydrophilic priming
  • Lot-to-lot QC

Assembly, automation & QC

Turnkey cartridge build-outs: membrane integration, reagent lyophilization, pump and valve integration, SBS-format plates compatible with standard handlers, plus dimensional, leak and burst testing on every lot.

  • Membrane lamination
  • Lyophilized reagents
  • Leak / burst / TEER QC
  • SBS automation-ready
02

How a program runs

Concept to clinical-grade supply in six gated stages

STAGE 1

Discovery & NDA

Technical deep-dive on your assay, organoid model and throughput target. NDA within 48 hours.

Week 0–1
STAGE 2

DFM & quotation

Architecture review, material and process selection, CAD/GDS readiness, fixed-fee quote per stage.

Week 1–3
STAGE 3

Prototyping

PDMS or machined thermoplastic iterations with defined test criteria: flow, bonding, cell viability.

Week 3–8
STAGE 4

Design verification

Verification builds against your acceptance protocol; dimensional, leak, burst and surface QC reports.

Week 8–14
STAGE 5

Pilot production

Tooling, cleanroom molding process lock, first article inspection, assembly line qualification.

Week 14–24
STAGE 6

Volume supply

ISO 13485-controlled release, lot traceability, capacity ramp to millions of cartridges per year.

Ongoing


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